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Prevalence of Reactive Hepatitis B Core Antibody among Healthy Blood Donors with Non-Reactive Hepatitis B Surface Antigen in a Tertiary Medical Center

Marie A. Barrientos,MD, Gene Bernabe, MD & Katrina Bonavente, MD
Virgilio Bañez, MD*


Rationale: Hepatitis B virus (HBV) infection is a global health problem, with 2 billion people infected worldwide. It has been considered as the 10th leading cause of death worldwide and is transmitted through blood transfusion. Blood products with occult HBV can be a threat when hepatitis B core antibody (anti-HBc) is not screened. Anti-HBc is an important serological marker for detection of cases for occult Hepatitis B infection and for reducing the residual risk of HBV transmission.
Objective: To determine the prevalence of reactive anti-HBc in the serum samples with non-reactive HBsAg among healthy blood donors in a tertiary medical center from April -August 2016.
Methods: A total of 209 blood donors were screened at Manila Doctors Hospital blood bank for the study from April to August 2016. Blood samples were screened using enzyme linked Immunosorbent assay (ELISA).
Results: Of the 209 donors screened, five donors yielded positive for HBsAg and were excluded from the study. The 204 donors were analyzed for anti-Hbc, 35 participants (17.16%) tested positive for anti- HBc.
Conclusion: The study was able to demonstrate a high prevalence rate of donors with anti -HBc among those with negative HBsAg.

*Adviser/Consultant, Department of Internal Medicine