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A Meta-Analysis on Proton Pump Inhibitors and Its Risk of Developing Acute Kidney Injury

Desiree N. Afaga, MD & Albert Rollorazo, MD
Russel Villanueva, MD*


Background: Proton pump inhibitors (PPI) are widely used for the treatment of acid-related disorders of the gastrointestinal tract. PPIs have demonstrated a favorable efficacy and safety profile. However, several case reports have suggested PPI use may be linked to acute kidney injury. The objective of this study was to determine if an association between PPI use and kidney failure exists.
Research Question and Objective: Among patients who are on proton pump inhibitor (PPI) use, what is the risk of developing Acute Kidney Injury (AKI)?
Selection Criteria: Patients who are on PPI use developing AKI
Search Methods: Pubmed
Data Collection and Analysis: The articles were reviewed by the two authors. Articles containing subjects who already have kidney injury were excluded from the study. Review Manager software ver. 5 was used to analyze the data collected from the articles.
Main results: There was a significant number of subjects who developed AKI on PPI use.
Authors’ conclusions: The study showed that there is a significant number of populations who developed AKI after being exposed to use of PPI.

*Adviser/Consultant, Department of Internal Medicine