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Correlation of Lamina Cribrosa and Standard Automated Perimetry Findings in Glaucomatous and Non-glaucomatous Eyes

Ian J. Daguman, MD
Manuel S. Delfin Jr., MD*

ABSTRACT

Purpose: To assess the correlation between lamina cribrosa thickness and prelaminar volume with standard automated perimetry results in glaucomatous and non-glaucomatous eyes.
Design: Cross-sectional, single-center, single observer, comparative study.
Participants: Forty-eight from twenty-two glaucoma and twenty-six non-glaucoma patients were included.
Methods: This is a single center, single observer, cross-sectional study. Eyes were categorized as glaucomatous or non-glaucomatous using the Lamina Cribrosa Exploration Study (Bundang Hospital Glaucoma Clinic of the Seoul National University). The glaucoma group was further sub-categorized based on their severity (mild, moderate or severe) based on the modified Hodapp-Anderson-Parish criteria. Visual field testing was done using Humphrey Field Analyzer Cirrus 5000 (Swedish Interactive Threshold Algorithm 30–2; Carl Zeiss Meditec, Dublin, CA). This study was approved by the Institutional Review Board of the Manila Doctors Hospital.
Main Outcome Measures: The lamina cribrosa thickness, prelaminar volume, and severity of glaucoma. Correlations between the lamina cribrosa thickness and visual field test results of glaucoma and non- glaucoma patients were analyzed using Spearman correlation. Comparison of lamina cribrosa thickness between glaucoma and non-glaucoma groups were analyzed with independent t-test. Comparison of lamina cribrosa thickness across glaucoma severities were analyzed using analysis of variance (ANOVA). 5% level of significance was employed.
Results: There was a significant difference in the lamina cribrosa thickness between glaucomatous and non-glaucomatous eyes (t = -1.842, p = 0.036). However, there is no significant difference in the pre- laminar thickness between glaucomatous and non-glaucomatous eyes (t = -0.704, p = 0.2425). In the glaucoma group, there was no statistically significant difference in the lamina cribrosa thickness between different glaucoma severities (f = 0.406, p = 0.672). There is no strong correlation between the lamina cribrosa depth and thickness to the severity of visual field test results (LC depth r = 0.239, p = 0.102), (LC thickness r = 0.160, p = 0.274). There was no significant difference in the comparison between mild glaucoma and non-glaucomatous eyes. However, there is a statistically significant difference in the lamina cribrosa thickness between moderate glaucoma and non-glaucomatous eyes (t = -1.974, p = <0.02852).
Conclusion: Lamina cribrosa thickness was significantly different between glaucoma and non-glaucoma groups. Speicifically, lamina cribrosa thickness between moderate glaucoma and non-glaucoma subjects have a statistically significant difference, it can be used as anothe r index in fortifying glaucoma as a diagnosis. Changes in the lamina cribrosa may have not been evident in early or mild glaucoma owing to its age-related stiffness. In this study, the mean age of glaucoma subjects is at 61.50 years and 58.20 years in non-glaucoma subjects.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

*Adviser/Consultant, Department of Ophthalmology

2018-03-06T12:25:30+00:00